Publications
2025
Necrosis drives susceptibility to Mycobacterium tuberculosis in PolgD257A mutator mice
Mabry et al., Infection & Immunity
2024
The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle
Azam et al., PNAS
Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
Scott et al., Cell Reports
2023
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection
Ellzey et al., Current Opinion in Immunology
Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis
Weindel et al. Trends in Cell Biology
2022
SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of Bax
Wagner et al., Elife
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Weindel et al., Cell
2021
Galectin-8 senses phagosomal damage and recruits selective autophagy adapter Tax1BP1 to control Mycobacterium tuberculosis infection in macrophages
Bell et al., mBio
Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis infection
Patrick and Watson, Infection and Immunity
Global transcriptomics uncovers distinct contributions from splicing regulatory proteins to the macrophage innate immune response
Wagner, Scott, West et al., Frontiers in Immunology
The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferons by engaging cytosolic DNA sensing in macrophages
Vail et al., PLOS Pathogens
2020
TRIM14 is a Key Regulator of the Type I IFN response during Mycobacterium tuberculosis infection
Hoffpauir et al., Journal of Immunology
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis
Weindel, Bell et al., Elife
2019
The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages
West et al., Cell Reports
Exploring the “multiple-hit hypothesis” of neurodegenerative disease: bacterial infection comes up to bat
Patrick et al., Frontiers in Cellular and Infection Microbiology
2018
Quantitative yeast genetic interaction profiling of bacterial effector proteins uncovers a role for the human retromer in Salmonella infection
Patrick et al., Cell Systems
2016
For better or worse: cytosolic DNA sensing during intracellular bacterial infection induces potent innate immune responses
Patrick, Bell et al., Journal of Molecular Biology
Earlier worK from kristin and robbie (2017-2001)
The histone variant H2A.Z promotes splicing of weak introns (Patrick)
The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy (Watson)
Genetic interaction mapping reveals a role for the SWI / SNF nucleosome remodeler in spliceosome activation in fission yeast (Patrick)
The ubiquitin ligase parkin mediates resistance to intracellular pathogens (Watson)
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway (Watson)
Hierarchal modularity and the evolution of genetic interactomes across species (Patrick)
Distinct and overlapping roles for two Dicer-like proteins in RNA interference pathways of the ancient eukaryote Trypanosoma brucei (Patrick)
Interaction of Campylobacter jejuni with host cells. (Watson)
Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysososomes (Watson)
Genomic rearrangements and transcriptional analysis of spliced leader associated retrotransposon in RNA interference-deficient Trypanosoma brucei (Patrick)
A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection (Watson)
Unique features of a highly pathogenic Campylobacter jejuni strain (Watson)
Sexual dimorphism in campylobacteriosis (Watson)
Signal transduction in Campylobacter jejuni-induced cytokine production (Watson)
Rgg influences expression of multiple regulatory loci to co-regulate virulence factor expression in streptococcus pyogenes (Watson)
Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells (Watson)
Identification of Rgg-regulated exoproteins of Streptococcus pyogenes (Watson)